Scientific Literature
Clinical studies and research
related to our products

A Dietary Fiber

  • AACC Report (March 2001) “The Definition of Dietary Fiber”, Vol. 46, No. 3, Page 112.
  • Taisuke N., et al., (2006) An improved method for the quantitative analysis of commercial IMO products using the calibration curve of standard reagents. J. Appl. Glycosci. 53;215-222.
  • B.C. Tungland et al.; Comprehensive Reviews in Food Science and Food Safety; “Non-digestible oligo- and polysaccharides (Dietary Fiber): Their physiology and role in human health and food”, 2002, Vol. 1, page 73-92.
  • Hayakawa K., et al., (200) “Determination of saccharides in sake by HPLC with polarized photometric detection”, Biomed. Chromatogr 14 14:72-76.
  • Rycroft, C.E.; Jones, M.R.; Gibson, G.R.; Rastall, R.A. 2001. A comparative in vitro evalution of the fermentation properties of prebiotic oligosaccharides. J Appl. Microbiol. 91(5):878-887.

A Prebiotic

  • Rycroft, C.E., et al., (2001) A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J. Appl. Microbiol. 91(5):878 887.
  • Kohmoto, T., et al., (1988) Effect of isomalto-oligosaccharides on human fecal flora. Bifidobacteria Microflora 7(2):61-69.
  • Kaneko, T., et al., (1990) [Acute and chronic toxicity and mutagenicity studies on isomaltooligosaccharides, and the effect on peripheral blood lymphocytes and intestinal microflora. Shokuhin Eiseigaku Zasshi 31(5):394-403.
  • Qing, G., et al., (2003) Study on the regulative effect of isomaltooligosaccharides on human intestinal flora. Wei Sheng Yan Jiu 32(1):54-55.
  • Chen, H.-L., et al., (2001) Effects of isomalto-oligosaccharides on bowel functions and indicators of nutritional status in constipated elderly men. J. Am. Coll. Nutr. 20(1):44-49.
  • Kaneko, T., et al., (1993) Effects of isomaltooligosaccharides intake on defecation and intestinal environment in healthy volunteers. Nihon Kasei Gakkaishi 44(4):245-254.
  • Kohmoto, T., et al., (1991) Dose-response test of isomaltooligosaccharides for increasing fecal bifidobacteria. Agric Biol Chem 55(8):2157-2159.
  • Kaneko, T., et al., (1994) Effect of isomaltooligosaccharides with different degrees of polymerization on human fecal bifidobacteria. Biosci. Biotech. Biochem. 58(12), 2288-2290.
  • Claire L. Vernazza, et al., (2006) Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacteria. J. Appl. Microbiol. 100;846-853.

Helps Maintain Healthy Cholesterol Levels

  • Hsiao-Ling Chen, et al., (2001) Effects of Isomalto-oligosaccharideson bowel functions and indicators of nutritional status in constipated elderly men. J.Amer.College.Nutri., 20 (1), 44-49.

Helps Maintain Healthy Blood Sugar Levels

  • Sheng G.E., et al., (2006) Determination of Glycemic Index of Xylitol and Isooligosaccharide. Clin. J. Clin. Nutr., 14 (4); 235-237.
  • Hesta M., et al., (2001) The effect of a commercial high-fiber diet and an isomalto-oligosaccharide-supplemented diet on post-prandial glucose concentrations in dogs. J. Anim. Physiol, 85; 217-221.
  • Hesta, M; Roosen, W.; et al. (2003). Prebiotics affect nutrient digestibility but not fecal amonia in dogs fed increased dietary protein levels. British Journal of Nutrition 90, 1007-1014.

Helps in Minerals Absorption

  • Kashimura, J., et al., Biol Trace Elem Res., (1996) 54 (3):239-250, “The effects of isomaltulose, isomalt, and isomaltulose-based oligomers on mineral absorption and retention”.
  • Yushihiro, S., et al., J. Jpn. Soc. Nutr. Food Sci., (1993) 46, 123-129, “Effects of Fructooligosaccharides and other Shaccarides on Ca, Mg and P absorption in rats”.
  • Kashimura, J., et al., J. Nutri. Sci. Vitaminol (Tokyo), (1996) Feb; 42(1): 69-76, (The effects of isomaltulose-based oligomers feeding and calcium efficiency on mineral retention in rats”.
  • Mineo H., et al., (2001) Various indigestible saccharides enhance net calcium transport from the epithelium of the small and large intestine in rats in vitro. J. Nutr. 131, 3243-3246.
  • Takuya S., et al., British Journal of Nutrition (2004), 92, 751-755, “Various non-digestible saccharides increase intracellular calcium io concentration in rat small-intestinal enterocytes”.

Least Flatulence

  • Rycroft, C.E., et al., (2001) A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J. Appl. Microbiol. 91(5):878 887.

Helps Regulate Bowel Movement

  • Hsiao-Ling Chen, et al., (2001) Effects of Isomalto-oligosaccharideson bowel functions and indicators of nutritional status in constipated elderly men. J. Amer.College. Nutri., 20 (1), 44-49.
  • Hsueh-Fang Wang, et al., (2001) [Use of isomaltooligosaccharide in the treatment of lipid profiles and constipation in hemodialysis patients] J. Renal Nutri., 11 (2) 73-79.

Anticaires (Anti-Dental Cavity) Activity

  • Tsunehiro J, et al. (1997) Biosci Biotechnol. Biochem 61(8): 1317-22 “Caries-inducing activity of the hydrogenated derivative of an isomalto-oligosaccharide mixture in rats”.
  • Minami T, et al. (1989) Shoni Shikagaku Zasshi 27(4): 1010-7, “Caries inducing activity ofisomaltooligosaccharide in vitro and rat experiments”.
  • Tsunehiro, J., et al. (1997) Biosci Biotechnol. Biochem. 61(12): 2015-8, “Effects of a hydrogenated isomalto-oligosaccharide mixture on glucan synthesis and on caries development in rats”.
  • Toshiyuki, K., et al. (1995) Biosci. Biotechnol. Biochem. 59(3): 372-377, “Evaluation of acidogenicity of commercial isomalto-oligosaccharide mixture and its hydrogenated derivative by measurement of pH response under human dental plaque”.

Use in Cosmetics

  • Bockmuhl, D., Jassory, C., et al. (2007) Intl. J. Cosmetics Science, 29, 63-66.

Caloric Value

  • Roberfroid MB., (1999) Caloric value of inulin and oligofructose. J. Nutr. 129, 1436-1437S

Digestibility

  • Kaneko, T.; Kohmoto, T.; Kikuchi, H.; Fukui, F.; Shiota, M.; Yatake, T.; Takaku, H.; lino, H. 1992. [Digestibility of isomalto-oligosaccharides by rats and effects on serum lipids]. Nippon Nogeikagaku Kaishi 66(8): 1211-1220 [Japanese with English summary].
  • Hesta, M., Roosen, W., et al. (2003). Prebiotics affect nutrient digestibility but not fecal ammonia in dogs fed increased dietary protein levels. British Journal of Nutrition 90, 1007-1014.
  • Kaneko, T.; Yokoyama, A.; Suzuki, M. 1995. Digestibility characteristics of isomalto-oligosaccharides in comparison with several saccharides using the rat jejunum loop method. Biosci. Biotechnol. Biochem. 59(7): 1190-1194.
  • Koshmoto, T.; Tsuji, K.,; Kaneko, T.; Shiota, M.; Fukiu, F.; Takaku, H.; Nakagawa, Y.; Ichikawa, T.; Kobayashi, S. 1992. Metabolism of 13C-isomalto-oligosaccharides in healthy men. Biosci. Biotechnol. Biochem. 56(6):937-940.
  • Tsunehiro, J.; Okamoto, K.; Furuyama, Y.; Yatake, T.; Kaneko, T. 1999. Digestibility of the hydrogenated derivative of an isomalto-oligosaccharide mixture by rats. Biosci. Biotechnol. Biochem. 63(9): 1515-1521.

Dose Tolerance

  • Bouhnik. Y.; Raskine, L.; Simoneau, G.; Vicaut, E.; Neut, C.; Flourie, B.; Brouns, F.; Bornet, F.R. 2004. The capacity of non-digestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study. Am. J. Clin. Nutri. 80(6): 1658-1664.
  • Chen, H.-L.; Lu, Y.-H.; Lin, J.-J.; Ko, L.-Y. 2001. Effects of isomalto-oligosaccharides on bowel functions and indicators of nutritional status in constipated elderly men. J. Am. Coll. Nutri. 20(1):44-49.
  • Kaneko, T.; Komoto, T.; Kikuchi, H.; Shiota, M.; Yatake, T.; lino, H.; Tsuji, K. 1993. [Effects of isomaltooligosaccharides intake on defecation and intestinal environment in healthy volunteers]. Ninon Kasei Gakkaishi 44(4):245-254 [Japanese with English summary].

Helps in Relieving Constipation

  • Hsueh-Fang Wang, et al., (2001) [Use of isomaltooligosaccharide in the treatment of lipid profiles and constipation in hemodialysis patients] J. Renal Nutri., 11 (2) 73-79.
  • Hsiao-Ling Chen, et al., (2001) Effects of Isomalto-oligosaccharideson bowel functions and indicators of nutritional status in constipated elderly men. J. Amer. College. Nutri., 20 (1), 44-49 .

Has a Low Glycemic Index (GI)

  • Sheng G.E., et al., (2006) Determination of Glycemic Index of Xylitol and Isooligosaccharide. Clin. J. Clin. Nutr., 14 (4); 235-237.

Low Calorie Health Sweetener

  • Roberfroid MB., (1999) Caloric value of inulin and oligofructose. J. Nutr. 129, 1436-1437S.
  • Nakanishi T., et al., (2006) An Improved method for the quantitative analysis of commercial isomalto-oligosacchride products using the calibration cure of standard reagents. J. Appl. Glycosci., 53, 215-222.

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